Delineation of the role of RasGRP4 in mast cell growth, differentiation and activation, using RasGRP4 deficient mice

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/630402

Funding Status
Closed

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Funded Activity Summary

Mast cells are important in immunity. Mast cells have been implicated in asthma and more recently they have been shown to participate in immunity against bacteria, viruses and fungi. We have identified a specific protein, RasGRP4, which is restricted to mast cells and plays an important role in their development and function. Understanding this molecule more extensively will give us a much better understanding of diseases that the mast cell is involved in such as asthma and other disorders.

Funded Activity Details

Start Date: 01-01-2010

End Date: 01-01-2012

Funding Scheme: NHMRC Project Grants

Funding Amount: $636,199.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Immunology not elsewhere classified

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Asthma | Bacterial and viral infections | Fibrosis | Inflammation | Mast cells | RasGRP4

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