Cellular responses to oligodendrcyte apoptosis: modeling the early pathogenesis of Multiple Sclerosis

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/628749

Funding Status
Closed

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Funded Activity Summary

In Multiple Sclerosis, oligodendrocytes (the myelin-producing cells of the brain) are damaged and myelin is lost. This process results in damage to nerve cells. We have generated a model of oligodendrocyte death that results in nerve cell damage. We will use this model to understand how nerve cells become damaged when oligodendrocytes die and whether the brain can make new oligodendrocytes to protect nerve cells from further damage.

Funded Activity Details

Start Date: 01-01-2010

End Date: 01-01-2012

Funding Scheme: NHMRC Project Grants

Funding Amount: $460,037.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Neurology and Neuromuscular Diseases

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

CNS repair after injury | Demyelination | Microglia | Multiple sclerosis | Neuronal injury | Oligodendrocyte | central nervous system demyelination and inflammation | disease models, animal | multiple sclerosis | neurodgenerative disease

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