Investigating Genetic Determinants of Absence Epilepsy in a Polygenic Rat Model

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/628723

Funding Status
Closed

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Funded Activity Summary

The underlying genetic causes of idiopathic generalised epilepsies (IGE) are still largely unknown. In an animal model of IGE we have discovered novel genetic abnormalities an ion channel. This proposal will build upon these novel findings to examine the role these abnormalities have in determining the absence epilepsy phenotype and this work has the potential to provide vital information regarding the mechanisms by which this gene contributes to an IGE seizure phenotype.

Funded Activity Details

Start Date: 01-01-2010

End Date: 01-01-2012

Funding Scheme: NHMRC Project Grants

Funding Amount: $458,481.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Central Nervous System

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Absence epilepsy | Calcium channels | Epilepsy | animal model | children's disease | epilepsy, generalized, tonic-clonic, absence, myoclonic | genetics, polygenic inheritance | mutations-polymorphisms | neurogenetics

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