Glucocorticoid resistance: identifying new anti-inflammatory drug targets

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/628691

Funding Status
Closed

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Funded Activity Summary

The control of chronic inflammatory diseases such as asthma involve use of drugs related to the steroid hormone cortisol. Up to 40% of patients with more severe disease respond poorly or not at all to these drugs. The remaining non-steroid treatments are only partially effective. Poor disease control is a great health and economic burden. We have identified a molecular mechanism for steroid resistance and propose new studies to identify novel drugs that act to reverse steroid resistance.

Funded Activity Details

Start Date: 01-01-2010

End Date: 01-01-2012

Funding Scheme: NHMRC Project Grants

Funding Amount: $453,287.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Basic Pharmacology

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

anti-inflammatory | asthma | cell proliferation | chronic obstructive lung disease (COPD) | cytokine and chemokines | glucocorticoid-resistance | inflammation | lung injury | rheumatoid arthritis | transforming growth factor beta

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