A novel knockin model to test the role of nicotine acting on alpha4 acetylcholine receptors in complex behaviours

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/628680

Funding Status
Closed

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Funded Activity Summary

Cigarette smoking is the single largest preventable cause of death and disease in Australia and worldwide. Nicotine contained in tobacco products acts on brain nicotine receptors, which plays an intrinsic role in addiction. One type of receptor for nicotine found in regions of the brain associated with drug-seeking behaviour is called alpha4 nicotinic receptors. We have made a mouse with a mutation in this nicotine receptor to study nicotine addiction and anxiety.

Funded Activity Details

Start Date: 01-01-2010

End Date: 01-01-2012

Funding Scheme: NHMRC Project Grants

Funding Amount: $581,315.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Central Nervous System

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

acetylcholine | addiction | anxiety disorders | nicotine dependence | nicotinic | nicotinic receptors | smoking

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