Understanding the role of PI 3-kinase mutations in gastrointestinal tumourigenesis

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/628621

Funding Status
Closed

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Funded Activity Summary

Mutations in the PIK3CA gene are frequently found in bowel cancers but it remains unclear exactly how these mutations are involved in cancer development. We will exploit a unique mouse model to explore the role of PIK3CA mutations in the initiation, progression and-or metastasis of gastrointestinal cancers. This work will provide critical new insights into the biology of PIK3CA mutations and lead to the development of better models for the testing of new anti-cancer therapies.

Funded Activity Details

Start Date: 01-01-2010

End Date: 01-01-2012

Funding Scheme: NHMRC Project Grants

Funding Amount: $283,880.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Gastroenterology and Hepatology

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Signal transduction | cancer biology | cell biology | cell signalling | colon cancer | mouse models of cancer | murine models | phosphatidylinositide 3-kinase | tumour biology

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