Studies on the tumour-associated PIK3CA(H1047R) mutation using in vitro and in vivo models of breast and ovarian cancer

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/628620

Funding Status
Closed

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Funded Activity Summary

PIK3CA mutations are frequently found in breast and ovarian cancers but how they cause cancer is not clear. We will exploit a unique mouse model to investigate the functional effects of PIK3CA mutations in cells and their role in cancer development. Understanding the mechanisms by which PIK3CA mutations regulate cell function and drive tumour growth will allow the rationale design of novel anti-cancer agents that specifically target this important cancer pathway.

Funded Activity Details

Start Date: 01-01-2010

End Date: 01-01-2012

Funding Scheme: NHMRC Project Grants

Funding Amount: $583,312.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Cancer Cell Biology

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Signal transduction | breast cancer | cancer biology | cell biology | cell signalling | mouse models of cancer | murine models | ovarian cancer | phosphatidylinositide 3-kinase | tumour biology

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