Local SAA production drives glucocortosteriod resistant airway inflammation in COPD

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/628511

Funding Status
Closed

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Funded Activity Summary

We have recently identified a blood marker termed SAA that is highly elevated during an acute attack of Chronic Obstructive Pulmonary Disease (COPD) mainly caused by chest infections. These episodes are a major cause of hospitalisation. Our previous studies suggest that by measuring blood SAA levels we can prevent a worsening of the attack with early intervention. We are now exploring the biological role of SAA and whether blocking SAA activity will benefit COPD patients.

Funded Activity Details

Start Date: 01-01-2010

End Date: 01-01-2013

Funding Scheme: NHMRC Project Grants

Funding Amount: $540,704.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Respiratory Diseases

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

COPD | Chronic Obstructive Pulmonary Disease | airway epithelium | airway inflammation | chronic inflammatory disease | corticosteroid treatment | corticosteroids | inflammation of respiratory tract | macrophage

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