Restoring skeletal muscle in an experimental model of COPD by targeting the IGF-1-myostatin-macrophage axis

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/628492

Funding Status
Closed

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Funded Activity Summary

Most people think that the serious disabilities of COPD (emphysema) patients follows damage to their lungs but wasted muscles may be even more important. We can not regrow lung but we have found a way that might help regrow muscle. We plan to use stem cells to make one of the body's own cells called 'macrophages' and genetically engineer these cells to help deliver healing proteins directly into the muscle. Making muscle stronger will help COPD patients live longer and improve quality of life.

Funded Activity Details

Start Date: 01-01-2010

End Date: 01-01-2014

Funding Scheme: NHMRC Project Grants

Funding Amount: $508,183.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Respiratory Diseases

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Chronic Obstructive Pulmonary Disease (COPD) | Inflammation | Macrophage | Mouse models of COPD | Skeletal muscle | Skeletal muscle wasting | Smoking | Weight loss

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