Specific roles of the transmembrane exoloops and the LDLa module in the activity of relaxin and INSL3 receptors

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/628427

Funding Status
Closed

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Funded Activity Summary

The peptide hormone relaxin is currently in clinical trials to treat acute heart failure. The related hormone INSL3 has important roles in fertility. We will continue our previously successful approaches to study the interaction of relaxin and INSL3 with their cell surface receptors and the mechanisms by which the receptors function. The knowledge gained will aid in the design of smaller, more potent and orally active forms of relaxin and INSL3 for future clinical applications.

Funded Activity Details

Start Date: 01-01-2010

End Date: 01-01-2012

Funding Scheme: NHMRC Project Grants

Funding Amount: $598,863.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Basic Pharmacology

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

G-protein coupled receptors | Molecular Pharmacology | NMR spectroscopy | cardiovascular disease | drug target | fibrosis | preeclampsia | regulatory peptides

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