The mechanism by which apical-basal polarity complexes regulate the Salvador-Warts-Hippo pathway

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/628401

Funding Status
Closed

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Funded Activity Summary

Cancer is a multi-hit process involving the activation of critical signaling pathways leading to increased proliferation, survival and increased invasion-metastasis. We have discovered that a neoplastic tumour suppressor gene, lgl, acts though the Salvador-Warts-Hippo (SWH) tumour suppressor pathway to inhibit cell proliferation and cell survival. Here we use the model organism, Drosophila, and mammalian epithelial cells to determine the mechanism by which Lgl activates the SWH pathway.

Funded Activity Details

Start Date: 01-01-2010

End Date: 01-01-2012

Funding Scheme: NHMRC Project Grants

Funding Amount: $540,099.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Cell Development, Proliferation and Death

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

cancer and related disorders | cancer: mechanisms of growth, invasion, metastases | cell death-apotosis | cell proliferation | proliferative disorders | protein phosphorylation | signalling pathways

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