Peptides Derived from ProGRP as Growth Factors for Gastrointestinal Cancers

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/628390

Funding Status
Closed

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Funded Activity Summary

Our objective is to determine the roles of a growth factor termed bombesin. This peptide, known as GRP in the human, is a growth factor in certain lung cancers but little is known about its role in tumours of the colon. This project is based on our novel observation that the precursor of GRP (proGRP) previously thought to be inactive is in fact active in stimulating the growth of colon cancer cells. A successful outcome will result in novel treatments such as proGRP antagonists.

Funded Activity Details

Start Date: 01-01-2010

End Date: 01-01-2012

Funding Scheme: NHMRC Project Grants

Funding Amount: $589,544.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Gastroenterology and Hepatology

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

cancer and related disorders | colorectal cancer | gastrointestinal tumorigenesis | peptide processing | regulation of tumour growth | regulatory peptides

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