The role of thymocyte self-renewal in causing T cell leukaemia

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/628368

Funding Status
Closed

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Funded Activity Summary

Recurrence of acute leukamia after therapy is due to the presence of immature cells that can self-renew, a process that is normally restricted to stem cells. Through the study of mice that develop leukaemia, we have identified these very rare self-renewing cells that are resistant to standard therapies. We can identify and measure these cells many months before leukaemia develops. As such, we will use this mouse model to understand how these cells self-renew and how they can be killed

Funded Activity Details

Start Date: 01-01-2010

End Date: 01-01-2012

Funding Scheme: NHMRC Project Grants

Funding Amount: $586,594.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Haematological Tumours

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Cancer: mechanisms of growth, invasion, metastases | Gene targeting | Leukaemia in children | LeukaemiaTranscription factor | Targeted therapy | Transgenic animals

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