Direct characterisation of naive epitope-specific T cell populations and their influence on immune responses

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/628316

Funding Status
Closed

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Funded Activity Summary

CytotoxicT cells (CTLs) recognize and remove virus infected cells. Both the number and the diversity of T cells involved in the response influence viral clearance. We plan to use a novel technology to directly analyze the numbers and diversity of such CTLs in mice prior to infection. This will clarify how characteristics of cell populations prior to infection define the immune response after infection. This is critical for vaccine design to maximize the efficiency of the immune response.

Funded Activity Details

Start Date: 01-01-2010

End Date: 01-01-2012

Funding Scheme: NHMRC Project Grants

Funding Amount: $314,983.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Cellular Immunology

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Influenza | T cell immunity | T cell receptor repertoire | cytotoxic T cell | immune development | immunology | vaccination immunology | viral immunology | virus infection

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