Granzymes as regulators of inflammation

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/628302

Funding Status
Closed

Does something not look right? The information on this page has been harvested from data sources that may not be up to date. We continue to work with information providers to improve coverage and quality. To report an issue, use the .

Funded Activity Summary

Inflammatory processes are normally regarded as being initiated and maintained through the activities of white blood cell macrophages. We propose to explore the role of lymphocyte delivery of protease molecules termed granzymes in inflammation. Our preliminary data has demonstrated a novel paradigm involving amplification of septic shock through the activity of granzymes. We now wish to exlore these interactions at a cellular and biochemical level as a means to better understand inflammation.

Funded Activity Details

Start Date: 01-01-2010

End Date: 01-01-2012

Funding Scheme: NHMRC Project Grants

Funding Amount: $675,309.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Immunology not elsewhere classified

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Granzymes | Inflammation | Natural Killer cells | Tumor Immunology | bacterial sepsis | cancer chemotherapy | cytokines | inflammatory mediators

Related Links