Determinants of occurrence and progression of aortic stenosis in bicuspid and tricuspid valves.

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/627245

Funding Status
Closed

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Funded Activity Summary

Aortic stenosis (AS) is a major cause of cardiac failure and mortality in ageing Australians. AS occurs both in bicuspid aortic valves (BAV;0.5-1% of the population) and in anatomically tricuspid valves. There is an associated incremental risk of myocardial infarction. The research will investigate patients with BAV and with early AS in tricuspid valves, in order to examine the potential roles of loss of nitric oxide effect and of oxidant stress as predictors of AS development.

Funded Activity Details

Start Date: 01-01-2010

End Date: 01-01-2013

Funding Scheme: NHMRC Project Grants

Funding Amount: $546,394.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Cardiology (incl. Cardiovascular Diseases)

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Aortic stenosis | Bicuspid aortic valve | Endothelial dysfunction | Nitric oxide | Oxidative stress | Thioredoxin-interacting protein | Valvular heart disease

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