Alveolar macrophage zinc and zinc transporters and their role in phagocytosis

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/627223

Funding Status
Closed

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Funded Activity Summary

Zinc is an essential dietary component that serves a number of functions in the lungs. It is both an anti-oxidant and anti-inflammatory agent. Some airway inflammatory diseases such as emphysema may involve a critical loss of lung zinc. We believe that cigarette smoke causes the loss of zinc and this prevents the lung macrophages from working properly to clear bacteria and dead cells. This will provide a foundation for our long term goals of better clinical management of emphysema.

Funded Activity Details

Start Date: 01-01-2010

End Date: 01-01-2013

Funding Scheme: NHMRC Project Grants

Funding Amount: $288,975.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Nutritional Physiology

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

COPD | Cigarette smoke | Efferocytosis | Macrophage | Smoking | Zinc | Zinc deficiency | Zinc transporter

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