Double stranded RNA - the common pathogenic agent in expanded repeat genetically inherited neurodegenerative diseases

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/627183

Funding Status
Closed

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Funded Activity Summary

At least twenty human genetic diseases are due to the expansion of existing repeat sequences beyond a common threshold copy number. While many of these diseases have a common mutation mechanism and share many clinical features the molecular steps critical to their pathogenesis are not yet understood. This project will test the hypothesis that expanded repeat containing RNA, specifically in its double-stranded form, is a common pathogenic agent in many of these diseases.

Funded Activity Details

Start Date: 01-01-2010

End Date: 01-01-2013

Funding Scheme: NHMRC Project Grants

Funding Amount: $605,096.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Genetics not elsewhere classified

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Drosophila models of human genetic disease | Huntington's Disease | RNA editing pathways | Spinocerebellar ataxia | dominant RNA pathogenesis | dynamic mutations | expanded repeat genetic diseases | late onset movement disorders | neurodegenerative disease

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