Understanding and controlling PAS domain interactions in basic helix-loop-helix transcription factors

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/627140

Funding Status
Closed

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Funded Activity Summary

We want to understand how particular proteins control the activity of genes that are a crucial part of the body's ability to respond to environmental stresses, such as low oxygen, seizure and environmental pollutants. The knowledge gained will help decipher the events that result in correct function in the cell, and the misregulation that leads to toxic outcomes and disease states. We will search for new compounds with potential application as therapeutics for cancer, heart disease and stroke.

Funded Activity Details

Start Date: 01-01-2010

End Date: 01-01-2012

Funding Scheme: NHMRC Project Grants

Funding Amount: $599,918.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Characterisation of Biological Macromolecules

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

DNA-protein interactions | drug development | drug metabolism and xenobiotics | embryonic development | ischemia | molecular mechanisms | protein structure | protein-protein interactions | transcriptional regulation | tumourigenesis

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