Preventing impaired beta-cell plasticity, insulin secretion and diabetes after IUGR

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/627123

Funding Status
Closed

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Funded Activity Summary

Babies who are born small are at increased risk of later diabetes, partly because restricting growth before birth also impairs development of insulin-secreting cells in the pancreas, impairing later insulin secretion and contributing to diabetes. We will define the mechanisms underlying impaired insulin secretion in a well-established animal model of fetal growth restriction. Importantly, we will also test interventions to improve insulin secretion after intrauterine growth restriction.

Funded Activity Details

Start Date: 01-01-2010

End Date: 01-01-2012

Funding Scheme: NHMRC Project Grants

Funding Amount: $760,611.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Foetal Development and Medicine

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

diabetes prevention | epigenetics | fetal origins of adult disease | insulin secretion | intervention study | intrauterine growth restriction | non-insulin dependent diabetes | plasticity

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