Modulation of macrophage function as a therapy for chronic obstructive pulmonary disease (COPD)

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/626972

Funding Status
Closed

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Funded Activity Summary

We have established that defective clearance of dying cells by phagocytes in the airway can a) perpetuate inflammation in smokers with-without COPD and b) be improved by administration of therapies (Mannose binding lectin and Procysteine) in a mouse model. The current proposal specifically addresses the role of phagocytes in the ongoing airway damage in our COPD patients, and more thoroughly investigates the mechanisms and effects of administration of relevant new therapies (in a mouse model).

Funded Activity Details

Start Date: 01-01-2010

End Date: 01-01-2013

Funding Scheme: NHMRC Project Grants

Funding Amount: $435,589.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Respiratory Diseases

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Airway inflammation | Chronic obstructive pulmonary disease | Smoking related diseases | Treatment of respiratory disease | chronic obstructive pulmonary disease (COPD) | cigarette smoking | macrophage | phagocytosis | phenotype and function

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