Klf5 function in normal and leukaemic haemopoiesis

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/626946

Funding Status
Closed

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Funded Activity Summary

Acute Myeloid Leukaemia (AML) is a devastating disease that affects both children and adults. New treatments that target particular genetic abnormalities are urgently needed. We have identified KLF5 as a gene that may control blood cell maturation. In AML patient samples we have found alterations of the KLF5 gene that may suppress its activity and contribute to the formation of leukaemia. These leukaemias may be good candidates for treatment with new drugs called methyltransferase inhibitors.

Funded Activity Details

Start Date: 01-01-2010

End Date: 01-01-2012

Funding Scheme: NHMRC Project Grants

Funding Amount: $609,924.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Haematology

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Acute Myeloid Leukaemia | Cancer | Gene regulation | Haemopoiesis | Leukaemia | Mechanisms inhibiting cancer cell growth | Myelopoiesis | Transcription factor

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