Role of sphingosine kinase 1 in PP2A-associated tumorigenesis

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/626937

Funding Status
Closed

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Funded Activity Summary

Defects in protein phosphatase 2A (PP2A) are widely associated with the development of solid tumors and leukemia. The precise mechanisms whereby defects in PP2A lead to cancer, however, remain undefined. We have recently identified that the oncogenic protein sphingosine kinase 1 (SK1) as a target of PP2A. In this study we will examine the role of SK1 in PP2A-associated cancers. Successful outcomes in these studies will establish SK1 as a target for therapeutic intervention in these cancers.

Funded Activity Details

Start Date: 01-01-2010

End Date: 01-01-2012

Funding Scheme: NHMRC Project Grants

Funding Amount: $522,994.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Signal Transduction

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

biochemistry and molecular biology | cancer biology | cell signalling | enzyme regulation | lipid metabolism | molecular basis of disease | phosphoprotein | phosphorylation

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