Mechanisms of regulation and biological roles of sphingosine kinase 2

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/626936

Funding Status
Closed

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Funded Activity Summary

We have identified that a protein called sphingosine kinase 2 (SK2) is a potential target for anti-cancer therapies. Our preliminary studies indicate that phosphorylation of SK2 controls its function. In this proposal we will define how phosphorylation alters SK2 function so that potential therapies may be developed to target this process.

Funded Activity Details

Start Date: 01-01-2010

End Date: 01-01-2012

Funding Scheme: NHMRC Project Grants

Funding Amount: $517,989.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Signal Transduction

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

biochemistry and molecular biology | cancer biology | cell signalling | enzyme regulation | lipid metabolism | molecular basis of disease | phosphoprotein | phosphorylation

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