Characterisation of the tumour suppressor function of caspase-2

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/626905

Funding Status
Closed

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Funded Activity Summary

Aberrant cell death (apoptosis) is associated with many diseases including cancer. Apoptosis is mediated by a group of enzymes called caspases. Recently we have discovered that one of these enzymes, caspase-2, acts as a tumour suppressor. We now wish to validate this finding in several preclinical models of cancer and understand precisely how caspase-2 works to safeguard cells against cancer development. These studies will help better understand cancer and ways to treat it.

Funded Activity Details

Start Date: 01-01-2010

End Date: 01-01-2012

Funding Scheme: NHMRC Project Grants

Funding Amount: $605,096.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Cancer Cell Biology

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

biochemistry and molecular biology | cancer | cancer biology | caspases | cell biology | cell death | cell death-apoptosis | cell proliferation | cell survival | disease models, animals

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