Synchrotron X-ray assessment of airway surface physiology for cystic fibrosis

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/626863

Funding Status
Closed

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Funded Activity Summary

We seek a cure or long-lasting therapy for the fatal airway disease in cystic fibrosis. Disease is caused by a shallow and dehydrated airway surface liquid (ASL), allowing bacteria to infect the lung. We can introduce a corrective gene into mouse airways where it can be effective for over 1 yr, but no fast, accurate and non-invasive measurement exists to test if treatments are successful. We will develop methods using synchrotron light to directly measure ASL depth changes in live mouse airways.

Funded Activity Details

Start Date: 01-01-2010

End Date: 01-01-2014

Funding Scheme: NHMRC Project Grants

Funding Amount: $778,228.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Respiratory Diseases

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

airway surface liquid | chronic disease | cystic fibrosis | gene therapy | gene transfer | lentivirus | non-invasive assessment of lung pathology | pediatric respiratory disease | synchrotron X-ray imaging

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