Effects of Ephrin-Eph and PTHrP signalling on osteosarcoma.

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/620203

Funding Status
Closed

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Funded Activity Summary

Osteosarcoma (OS) is the most common bone cancer in children, with ~170 cases per year in Australia. We used genetic mutation of mice to induce OS that is very similar to human OS. The OS produces parathyroid hormone-related protein and ephrins and responds to both proteins. We will study how the cancer develops and spreads, and how this is affected by these two pathways, both of which are implicated in cancer development, and could be targets for treatment.

Funded Activity Details

Start Date: 01-01-2010

End Date: 01-01-2012

Funding Scheme: NHMRC Project Grants

Funding Amount: $646,486.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Oncology and Carcinogenesis not elsewhere classified

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

bone | bone cancer | bone development | cancer | cancer biology | cell differentiation | childhood cancer | mouse model | osteoblastic lesions | osteosarcoma

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