Inhibition of interferon-alpah-beta by chikungunya virus and the induction of arthritis

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/613622

Funding Status
Closed

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Funded Activity Summary

Chikungunya virus is a mosquito borne virus which has caused epidemics of arthritis around the world (recently 260,000 people Reunion Island, France and 1.6 million people in India). The virus is ordinarily very sensitive to the main mammalian anti-viral defence system (interferon alpha-beta). This grant seeks to understand how, despite the activation of this system during infection, the virus manages to persist and cause 3-6 months of debilitating arthritis.

Funded Activity Details

Start Date: 01-01-2010

End Date: 01-01-2013

Funding Scheme: NHMRC Project Grants

Funding Amount: $709,193.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Medical Virology

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

arthritis | inflammatory arthritis | innate immunity | interferon | viral pathogenesis | viral persistence

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