Genetics of intersex: Antagonism between male and female pathways during gonadal development

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/611810

Funding Status
Closed

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Funded Activity Summary

Disorders of sex Development (DSD) are congenital conditions in which development of chromosomal, gonadal or anatomical sex is atypical. Estimates suggest that between 1-100 and 1-300 live birth have DSD; however, the underlying genetic defect is unknown in 80% of cases. Generally, the fate of the gonad, testis or ovary, is determined by the balanced action of male (SRY) and female (Wnt- b-catenin) genes. How do these genes oppose each other? Is this antagonism deregulated in DSD patients?

Funded Activity Details

Start Date: 01-01-2010

End Date: 01-01-2012

Funding Scheme: NHMRC Project Grants

Funding Amount: $567,760.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Developmental Genetics (incl. Sex Determination)

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

SOX genes | disorders of sex development | embryonic development | geneticdisease | gonadal development | molecular genetics | reproduction | sex determination | signalling pathways | transcriptional regulation

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