Critical Role of Proprotein Convertase 6 in Human Uterine Epithelium for Embryo Implantation and Clinical Implications

Funding Activity

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Funded Activity Summary

Implantation of an embryo into the uterus is a key step for human development. Implantation failure causes embryonic death, pregnancy loss and infertility. Conversely, preventing implantation is an attractive approach for contraception. We have established that proprotein convertase 6 (PC6) is a master regulator of implantation. We will investigate how PC6 works in a woman's uterus, and how we can use this knowledge to improve implantation in IVF and to develop PC6 drugs for new contraceptives.

Funded Activity Details

Start Date: 01-01-2010

End Date: 01-01-2012

Funding Scheme: NHMRC Project Grants

Funding Amount: $643,899.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Obstetrics and Gynaecology

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Contraception | Embryo implantation | Female infertility | Fertility | Pregnancy | Reproduction | Uterine epithelium | Uterine receptivity | Uterus