Does remote ischemic preconditioning induce protective mitochondrial function in congenital heart defect repair surgery?

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/607404

Funding Status
Closed

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Funded Activity Summary

The body's own protective mechanism against injury due to reduced blood flow (ischemic preconditioning) has been studied for over 2 decades, yet the clinical benefits have not been realised until recently . We have previously shown that this innate protection can be induced without drugs in children having heart surgery. We will extend these findings to determine the mechanism of protection, develop a method to monitor this in blood cells and see if this is related to post-operative outcomes.

Funded Activity Details

Start Date: 01-01-2010

End Date: 01-01-2011

Funding Scheme: NHMRC Project Grants

Funding Amount: $142,759.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Paediatrics

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Congenital heart disease | Myocardial cardioplegic ischaemia | Paediatric heart surgery | Remote ischaemic preconditioning | Tetralogy of Fallot | congenital heart corrective surgery | hypoxia | ischaemia-reperfusion injury | myocardial protection | remote ischaemic preconditioning

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