Bone-specific sclerostin and SIBLING proteins in osteoarthritis: novel contributions to cartilage and bone pathology

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/607399

Funding Status
Closed

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Funded Activity Summary

Arthritis is a major clinical problem and involves the destruction of cartilage in joints. However, the mechanisms of how this cartilage destruction is initiated and progresses remain poorly understood. We recently discovered that that three proteins that play a role in bone are also produced in cartilage and are increased in cartilage during osteoarthritis. We will determine the role of each of these in the disease mechanism to provide new therapeutic and biomarker targets.

Funded Activity Details

Start Date: 01-01-2010

End Date: 01-01-2011

Funding Scheme: NHMRC Project Grants

Funding Amount: $441,058.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Orthopaedics

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

arthritis | bone | bone metabolism | cartilage | cartilage damage | cartilage degeneration | extracellular matrix | osteoarthritis

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