The unfolded protein stress response in inherited skeletal disease: mechanism and therapeutic strategies

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/607398

Funding Status
Closed

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Funded Activity Summary

In genetic diseases, gene mutations commonly cause proteins to fold abnormally. This can cause cell stress resulting in cell death. Our studies will determine the role of cell stress in a clinically important group of skeletal diseases caused by collagen mutations. We will also test how we can use small chemicals to alleviate the damage done to the cells by the misfolded proteins, in the hope that this approach will provide new therapeutic strategies for these disorders.

Funded Activity Details

Start Date: 01-01-2010

End Date: 01-01-2012

Funding Scheme: NHMRC Project Grants

Funding Amount: $549,092.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Cellular Interactions (incl. Adhesion, Matrix, Cell Wall)

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

chemical chaperones | chondrodysplasaia | collagen disease | endoplasmic reticulum stress | inherited bone disease | inherited cartilage disease | inherited musculoskeletal disease | osteogenesis imperfecta | unfolded protein response

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