Structural characterisation function analyses of type I interferon-receptor interactions

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/606931

Funding Status
Closed

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Funded Activity Summary

The interferons are an essential component of the body's response to infectious and inflammatory disease and cancer. In order to design the best therapeutic approaches to modulate interferon activity, we need a defined understanding of how IFN binds to its receptor on target cells and activates its functions. This project will characterize these interactions in cells, mice and molecules with x-ray crystallography and the synchrotron to solve the structure and facilitate informed drug design.

Funded Activity Details

Start Date: 01-01-2010

End Date: 01-01-2012

Funding Scheme: NHMRC Project Grants

Funding Amount: $517,989.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Characterisation of Biological Macromolecules

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

060110 Receptors and membrane biology | 060111 Signal transduciton | 110707 Innate Immunity | autoimmune disease | cancer therapy | infectious diseases | inflammatory diseases | interferon therapy

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