Selective targeting of acute renal injury by inhibition of the receptor tyrosine kinase, c-fms.

Funding Activity

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Funded Activity Summary

The progression of kidney disease to end-stage renal failure is a major health problem in our community. We have identified that macrophages, a type of white blood cell, plays an important role in causing inflammatory kidney injury. This project will use clinically relevant animal models to test the therapeutic potential of our new approach to selectively remove these cells from the inflamed kidney and thereby protect it from injury.

Funded Activity Details

Start Date: 01-01-2010

End Date: 01-01-2013

Funding Scheme: NHMRC Project Grants

Funding Amount: $443,007.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Nephrology and Urology

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Inflammation | Ischaemic acute renal failure | Ischemia-reperfusion injury | Kidney | Kidney diseases | Kidney transplantation | Lupus nephritis | Macrophage | Organ transplantation | Pathogenic mechanisms