Does loss of melanocortin glucose sensing contribute to obesity induced diabetes?

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/606662

Funding Status
Closed

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Funded Activity Summary

Diabetes is a failure to properly regulate blood glucose levels. Escalating rates of diabetes are a major health problem. Melanocortin neurons in the brain detect blood sugar levels and usually regulate glucose production and utilization, but in obese animals they do not. We have developed a possible therapeutic, which appears to reverse the glucose insensitivity, and rapidly reduces blood glucose in diabetic mice. This project will determine how melanocortins act to regulate glucose levels

Funded Activity Details

Start Date: 01-01-2010

End Date: 01-01-2012

Funding Scheme: NHMRC Project Grants

Funding Amount: $617,531.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Endocrinology

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Central autonomic control | Insulin resistance | Obesity | POMC | Type 2 Diabetes | Type 2 diabetes | glucose | liver | obesity pathogenesis

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