To understand the role of the plasminogen activating and matrix metalloproteinase systems in traumatic brain injury

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/606660

Funding Status
Closed

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Funded Activity Summary

Tissue-type plasminogen activator (t-PA) is known for its role as a clot dissolving protein. It is present in the brain and following traumatic brain injury (TBI), it can worse brain cell damage. We have established a mouse model of TBI . We will compare brain damage in mice that are deficient in or have high amounts of t-PA. We will also determine whether the recovery rate post-TBI can be improved using specific t-PA blockers. This project may provide new therapies for TBI.

Funded Activity Details

Start Date: 01-01-2010

End Date: 01-01-2012

Funding Scheme: NHMRC Project Grants

Funding Amount: $499,321.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Central Nervous System

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Animal model | Traumatic brain injury | Traumatic brain injury-neurotrauma | blood brain barrier | disease models, animal | matrix metalloproteinase | matrix metalloproteinases | neuronal responses to injury | oedema | tissue-type plasminogen activator

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