To investigate how the aggregation of proteins during neuronal injury promotes neurotoxic plasmin formation

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/606659

Funding Status
Closed

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Funded Activity Summary

tPA is an enzyme given to patients to remove stroke-causing blood clots but can have harmful effects in the brain. tPA needs a cofactor to function optimally. In the blood, this cofactor is fibrin. However the cofactor that allows tPA to function in the brain is unknown. This project explores a novel cofactor for tPA in the injured brain. We will attempt to block this harmful cofactor in the brain while still allowing tPA to remove clots thereby improving stroke outcome.

Funded Activity Details

Start Date: 01-01-2010

End Date: 01-01-2012

Funding Scheme: NHMRC Project Grants

Funding Amount: $586,428.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Neurosciences not elsewhere classified

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

acute ischaemic stroke | cardiovascular disease - stroke | improving outcome and safety for thrombolysis in stroke | neuronal cell death | neuronal injury | plasminogen | protein aggregation | stroke

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