Intracellular trafficking of copper and platinum-based chemotherapuetics

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/606609

Funding Status
Closed

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Funded Activity Summary

Platinum-based anti cancer drugs such as Cisplatin are effective against a number of cancers of the head, colon, lungs and ovaries. Tumour resistance to these drugs has been closely associated with changes in genes that control the movement of copper in and out of cells. We hypothesize that the same genes regulate distribution of both copper and Cisplatin. By investigating these pathways, we aim to find ways to predict and prevent tumour resistance to this important anti cancer treatment.

Funded Activity Details

Start Date: 01-01-2010

End Date: 01-01-2013

Funding Scheme: NHMRC Project Grants

Funding Amount: $268,328.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Cell Metabolism

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

alzheimer disease | angiogenesis | cancer | cisplatin | copper ion transport | drosophila | menkes disease | platinum-based chemotherapeutics | protein trafficking | wilson disease

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