Investigation of a New Approach to Regulate Fibrin Clot Retraction and Arterial Thrombolysis

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/606580

Funding Status
Closed

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Funded Activity Summary

Pathological blood clots are removed in patients by administering clot dissolving drugs (fibrinolytics). However these drugs are quite often ineffective and cause bleeding. We have identified a new platelet-mediated pathway controlling contraction of blood clots, important for clot stability. In this proposal, we will examine the potential for inhibitors of this pathway to loosen blood clots, and facilitate the actions of fibrinolytics to promote clot dissolution.

Funded Activity Details

Start Date: 01-01-2010

End Date: 01-01-2012

Funding Scheme: NHMRC Project Grants

Funding Amount: $483,171.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Haematology

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Fibrin clot retraction | Ischaemic stroke | Myocardial infarction | Platelets | Signalling - PI 3-kinase | Thromboembolic disease | Thrombolysis | Thrombolysis treatment | Thrombosis

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