Redox regulation of platelet adhesion receptors

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/606501

Funding Status
Closed

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Funded Activity Summary

Formation of clots to prevent blood loss is initiated by the platelet receptors, glycoprotein (GP)Ib-IX-V and GPVI. Unfortunately, there is a gap in our knowledge regarding the events immediately following activation of these receptors and the known downstream signalling. We have identified a novel binding partner for these platelet receptors, which we believe links reactive oxygen species to platelet signalling events. This opens new avenues for therapies to prevent aberrant clotting.

Funded Activity Details

Start Date: 01-01-2010

End Date: 01-01-2012

Funding Scheme: NHMRC Project Grants

Funding Amount: $592,661.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Haematology

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Cardiovascular disease | Glycoproteins | Haemostasis | Platelet aggregation | Reactive oxygen species | Signal transduction | Stroke | Thrombosis

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