The Role of MHC Class I Expression on Pancreatic Ductal Lineage Cells in the Pathogenesis of Type I Diabetes (TID).

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/606453

Funding Status
Closed

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Funded Activity Summary

MHC molecules act as traffic lights to the immune system telling it whether to stop or go, so that only when there is an infection does the immune system receive the signal to destroy target cells. However, the immune system in Type 1 Diabetes patients receives signals to destroy the insulin-producing cells when there is no apparent infection. We aim to determine where the faulty traffic signal occurs and so be in a better position to design intervention strategies to prevent Type 1 Diabetes.

Funded Activity Details

Start Date: 01-01-2010

End Date: 01-01-2013

Funding Scheme: NHMRC Project Grants

Funding Amount: $484,300.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Autoimmunity

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Autoimmune Diabetes | Class I restricted autoantigen presentation in NOD mice | Initiation of Type 1 Diabetes pathogenesis in NOD mice | Initiation of insulitis and beta cell destruction in NODmice | Insulin-dependent Diabetes | Islet beta cell destruction | Priming of diabetogenic CD8 T lymphcytes in NOD mice | Type 1 Diabetes

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