A new model of asthenospermia and a candidate gene for multiple ciliopathies

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/606445

Funding Status
Closed

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Funded Activity Summary

Though the analysis of a unique mouse strain (Mot1) we have identified a previously unknown cause of male infertility and lung disease. We hypothesis that the Mot1 line is a model of human primary cilia dyskinesia and that the Mot1 protein is involved in cilia function. Within this project we will define the consequences of a loss of Mot1 protein function, we will define its binding partners and we will screen for mutations in the corresponding human gene.

Funded Activity Details

Start Date: 01-01-2010

End Date: 01-01-2012

Funding Scheme: NHMRC Project Grants

Funding Amount: $629,039.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Reproduction

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

GTP binding protein | Infertility | bronchiectasis | genetic disease | lung pathology | male infertility | reproduction | reproductive disorders and fertility control

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