The role of PLZF in regulating the antiviral activity of interferons

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/606425

Funding Status
Closed

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Funded Activity Summary

Interferons are the first line of defence against viral infection. We have shown that the transcription factor promyelocytic leukemia zinc finger protein (PLZF) is a novel regulator of the interferon response. Thus we hypothesize that PLZF is a critical component of the host's innate immune system. This study will provide new insights into the understanding of signal transduction mechanisms, as well as improve our ability to modulate sensitivity to interferon to protect against viral diseases.

Funded Activity Details

Start Date: 01-01-2010

End Date: 01-01-2013

Funding Scheme: NHMRC Project Grants

Funding Amount: $652,005.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Signal Transduction

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

antiviral immunity | antiviral therapy | cell signalling | gene regulation | innate immunity | interferon | interferon non-responders | signalling pathways | transcription factor

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