Nuclear functions of Dengue NS5 protein: role in disease

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/606409

Funding Status
Closed

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Funded Activity Summary

Our work indicates that the NS5 protein from Dengue virus (DV) has distinct sequences that enable it to traffic into and out of the host cell nucleus to exert pathogenic effects on transcription and thereby impair the host cell anti-viral and immune responses. We aim to characterise these properties in detail, and demonstrate their importance to DV pathogenicity using a novel animal model of the disease.

Funded Activity Details

Start Date: 01-01-2010

End Date: 01-01-2012

Funding Scheme: NHMRC Project Grants

Funding Amount: $736,953.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Biochemistry and Cell Biology not elsewhere classified

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Dengue Virus | Dengue virus | NS5 protein | antiviral therapies | infectious diseases | intracellular transport | phosphorylation regulation | viral replication

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