Regulation of subcellular localisation of respiratory syncytial virus M protein: implications for pathology

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/606407

Funding Status
Closed

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Funded Activity Summary

Respiratory syncytial virus (RSV) is the major cause of viral pneumonia in infants and the elderly, causing more deaths in winter than influenza. We have observed RSV M protein in the nucleus of infected host cells where it inhibits host cell transcription. We propose to investigate the regulation of nuclear localisation of M by phosphorylation and binding to cellular factors and its importance to RSV pathogenesis. The results will relate strongly to future drug and vaccine development.

Funded Activity Details

Start Date: 01-01-2010

End Date: 01-01-2012

Funding Scheme: NHMRC Project Grants

Funding Amount: $580,195.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Infectious Diseases

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

asthma and respiratory diseases | matrix proteins | nuclear transport | pediatric respiratory disease | respiratory diseases | respiratory infections | respiratory syncytial virus | understanding virus-host interactions | virus pathogenesis

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