The role of ILK in Hedgehog signaling and medulloblastoma.

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/606404

Funding Status
Closed

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Funded Activity Summary

Molecular signaling pathways regulate normal embryo development, and deregulated signaling by these pathways causes many cancers. Hedgehog (Hh) is a signalling pathway commonly activated by mutations in specific genes to cause cancer, including medulloblastoma, the most common brain tumour of childhood. We have discovered novel protein interactions in the Hh pathway, and will use animal models of Hh-dependent medulloblastoma to investigate new anti-cancer drugs targetting these proteins.

Funded Activity Details

Start Date: 01-01-2010

End Date: 01-01-2012

Funding Scheme: NHMRC Project Grants

Funding Amount: $452,248.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Cancer Cell Biology

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

anti-cancer drugs | cancer | cancer biology | cell growth and differentiation | drug development | inhibition of cancer cell growth | murine models | oncogenesis | paediatric brain tumours | signalling pathways

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