Endothelial dysfunction as a therapeutic target in severe malaria

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/605807

Funding Status
Closed

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Funded Activity Summary

Even with very best drugs to kill malaria parasites, over 15% of patients with severe malaria still die. Their blood vessels are clogged up by malaria parasites. We have shown that the cells lining their blood vessels can't make enough nitric oxide to keep them non-sticky and allow blood through. We want to test whether giving arginine can 1) increase nitric oxide, 2) open up the clogged blood vessels and 3) dampen down other processes that clog up blood vessels in severe malaria.

Funded Activity Details

Start Date: 01-01-2010

End Date: 01-01-2013

Funding Scheme: NHMRC Project Grants

Funding Amount: $842,329.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Infectious Diseases

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Adjunctive therapies | Basis of disease in falciparum malaria | Endothelial dysfunction | L-arginine and nitric oxide | PGP3 | Plasmodium falciparum malaria | Randomised controlled trial | malaria | tropical medicine

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