Role of the hypoxia-inducible transcription factor HIF-1a in controlling haematopoietic stem cell fate

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/604303

Funding Status
Closed

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Funded Activity Summary

Haematopoietic stem cells (HSCs) reside in the bone marrow (BM) and make all immune and blood cells. We have found that, in the areas of the BM where HSC normally live, the level of oxygen is very low (hypoxia) and decreases even further when HSC are forced to move into the blood in order to be collected for transplantation. This project is to better understand how oxygenation of the BM controls HSC behaviour and properties, and to evaluate its impact on HSC transplantation.

Funded Activity Details

Start Date: 01-01-2010

End Date: 01-01-2012

Funding Scheme: NHMRC Project Grants

Funding Amount: $586,428.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Haematology

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Bone marrow | G-CSF | Haematological disorders | Haematopoiesis | Haematopoietic stem cell mobilisation | Haematopoietic stem cell transplantation | Hypoxia | Leukocyte trafficking | Stem cell niche | Stem cell therapy

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