NFkB1 is a novel regulator of CD8+ T cell development and memory cell generation

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/603713

Funding Status
Closed

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Funded Activity Summary

This project is focused on understanding the role of a regulatory protein- NFkB1 and how it is capable of controlling the development of a class of white blood cells termed T cells. Using a mouse model, we reveal how the absence of NFkB1 is important for producing memory T cells. Studies are proposed to determine whether this is an novel way for generating long lived memory T cells against viral infections and cancer, and potentially a new strategy for vaccine development.

Funded Activity Details

Start Date: 01-01-2010

End Date: 01-01-2012

Funding Scheme: NHMRC Project Grants

Funding Amount: $438,039.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Cellular Immunology

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

T cell immunity | cancer immunology | cancer therapy | cell signalling | cellular immunity | immune regulation | immunologic memory | nuclear factor kappa-B (NF-KB) | thymus | vaccination

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